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BMS 604992 manufacturers
- BMS-604992
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- $2120.00
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2026-05-11
- CAS:674343-47-6
- Purity:
- Supply Ability: 10g
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| | BMS 604992 Basic information |
| Product Name: | BMS 604992 | | Synonyms: | BMS 604992;EX 1314;DFDPBEQMMOYQHK-GMUIIQOCSA-N;EX-1314 HCl;EX-1314 hydrochloride;EX-1314 hydrochloride, BMS-604992 | | CAS: | 674343-47-6 | | MF: | C24H32ClN7O5 | | MW: | 534.00778 | | EINECS: | | | Product Categories: | | | Mol File: | 674343-47-6.mol |  |
| | BMS 604992 Chemical Properties |
| | BMS 604992 Usage And Synthesis |
| Uses | BMS-604992 (EX-1314) is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. BMS-604992 demonstrates high-affinity binding (Ki=2.3 nM) and potent functional activity (EC50=0.4 nM). BMS-604992 can stimulate food intake in rodents[1]. | | in vivo | BMS-604992 (500 μg/kg; i.p.; 5 minutes) results in a significant increase in gastric emptying compared with vehicle-treated mice[1].
BMS-604992 (1~1000 mg/kg; p.o.; 1 hour) Shows a dose-linear increase in plasma concentrations at the 1 hour time point and elicits a dose-responsive increase in food intake relative to vehicle-treated controls, with a minimum effective dose of approximately 10 mg/kg[1].
BMS-604992 (300 mg/kg; p.o.; 5~20 minutes) produces a significant difference at the 5 minutes time point.[1].
BMS-604992 (500 μg/kg; i.p.; 4 hours) increases food intake approximately 2-fold compared with vehicle-treated controls[1]. | Animal Model: | C57BL/6 mice | | Dosage: | 500 μg/kg | | Administration: | I.p.; 5 minutes | | Result: | Resulted in a significant increase in gastric emptying compared with vehicle-treated mice.
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| Animal Model: | C57BL/6 mice | | Dosage: | 1~1000 mg/kg | | Administration: | P.o.; 1 hour | | Result: | Showed a dose-linear increase in plasma concentrations at the 1 hour time point and elicited a dose-responsive increase in food intake relative to vehicle-treated controls, with a minimum effective dose of approximately 10 mg/kg.
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| Animal Model: | SD rat | | Dosage: | 300 mg/kg | | Administration: | P.o.; 5~20 minutes | | Result: | Observed a significant difference at the 5 minutes time point.
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| Animal Model: | Male GhrR KO and WT mice | | Dosage: | 500 μg/kg | | Administration: | I.p.; 4 hours | | Result: | Increased food intake approximately 2-fold compared with vehicle-treated controls.
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| | References | [1] Charoenthongtrakul S, et, al. Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. J Pharmacol Exp Ther. 2009 Jun;329(3):1178-86. DOI:10.1124/jpet.108.150193 |
| | BMS 604992 Preparation Products And Raw materials |
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