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| | 2-Chloro-4-MethoxypyriMidin-5-aMine Basic information |
| Product Name: | 2-Chloro-4-MethoxypyriMidin-5-aMine | | Synonyms: | 2-Chloro-4-MethoxypyriMidin-5-aMine;2-CHLORO-4-METHOXYPYRIMIDIN-5-AMIN;2-chloro-4-methoxypyrimidine-5-ylamine;2-chloro-4-methoxy-5-Aminopyrimidine;2-Chloro-4-methoxypyrimidin-5-ylamine;5-Amino-2-chloro-4-methoxypyrimidine;5-Pyrimidinamine, 2-chloro-4-methoxy-;2-Chloro-4-methoxy-5-pyrimidinamine | | CAS: | 96833-41-9 | | MF: | C5H6ClN3O | | MW: | 159.57 | | EINECS: | | | Product Categories: | | | Mol File: | 96833-41-9.mol |  |
| | 2-Chloro-4-MethoxypyriMidin-5-aMine Chemical Properties |
| Boiling point | 349.6±22.0 °C(Predicted) | | density | 1.398±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 1.36±0.29(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 2-Chloro-4-MethoxypyriMidin-5-aMine Usage And Synthesis |
| Synthesis | General procedure for the preparation of 2-chloro-4-methoxypyrimidin-5-amine: sodium methanolate (0.5 M solution in methanol, 3.7 mL, 1.829 mmol) was slowly added to a solution of 2,4-dichloropyrimidin-5-amine (0.2 g, 1.220 mmol) in methanol (2.5 mL). The reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and quenched with deionized water. The organic and aqueous layers were separated and the aqueous layer was further extracted with ethyl acetate. All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound 2-chloro-4-methoxypyrimidin-5-amine as a brown solid (177 mg, 91% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 3.93 (s, 3H), 5.31 (br s, 2H), 7.73 (s, 1H).LC-MS analysis (Method B, ESI positive ion mode) showed a retention time t R of 1.6 min and a molecular ion peak m/z of 160 [M + H]+ . | | References | [1] Patent: US2013/345181, 2013, A1. Location in patent: Paragraph 0785
[2] Patent: WO2014/184234, 2014, A1. Location in patent: Page/Page column 71; 72
[3] Patent: WO2014/191632, 2014, A1. Location in patent: Page/Page column 56 |
| | 2-Chloro-4-MethoxypyriMidin-5-aMine Preparation Products And Raw materials |
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