BIO 5192
| 中文名称 | BIO 5192 |
|---|---|
| 中文同义词 | |
| 英文名称 | (2(S)-[1-(3,5-Dichlorophenylsulfonyl)-L-prolylaMino]-4-[N-Methyl-N-[2-[4-[3-(2-Methylphenyl)ureido]phenyl]acetyl]-L-leucylaMino]butyric acid ) |
| 英文同义词 | (2(S)-[1-(3,5-Dichlorophenylsulfonyl)-L-prolylaMino]-4-[N-Methyl-N-[2-[4-[3-(2-Methylphenyl)ureido]phenyl]acetyl]-L-leucylaMino]butyric acid );(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid;AMD 15057;BIO 5192;BIO-5192 (BIO5192);Butanoic acid, 2-[[[(2S)-1-[(3,5-dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]-, (2S)-;(S)-2-((S)-1-((3,5-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxamido)-4-((S)-4-methyl-2-(N-methyl-2-(4-(3-(o-tolyl)ureido)phenyl)acetamido)pentanamido)butanoic acid;Butanoic acid, 1-((3,5-dichlorophenyl)sulfonyl)-L-prolyl-N4-(N-methyl-N-((4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)acetyl)-L-leucyl)-2,4-diamino-, (2S)- |
| CAS号 | 327613-57-0 |
| 分子式 | C38H46Cl2N6O8S |
| 分子量 | 817.78 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 327613-57-0.mol |
| 结构式 |  |
BIO 5192 性质
| 熔点 | 134 - 136°C |
|---|---|
| 密度 | 1.380±0.06 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 二甲基亚砜（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.52±0.10(Predicted) |
| 颜色 | 白色至类白色 |
|
α4β1 1.8 nM (IC 50 ) |
α9β1 138 nM (IC 50 ) |
α2β1 1053 nM (IC 50 ) |
α4β7 >500 nM (IC 50 ) |
The combination of BIO5192 (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization.
BIO5192 (30 mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis).
BIO5192 (1 mg/kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 (3, 10, and 30 mg/kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h*ng/ml for the 3 mg/kg dose to 14,175 h*ng/ml for the 30 mg/kg.
| Animal Model: | C57BL/6J x 129Sv/J F1 mice |
| Dosage: | 1 mg/kg (with Plerixafor: 5 mg/kg) |
| Administration: | I.v. |
| Result: | Exerted an additive effect on progenitor mobilization. |
| Animal Model: | Healthy female Lewis rats weighing 150g |
| Dosage: | 30 mg/kg |
| Administration: | S.c; bid; during days 5 through 14 |
| Result: | Showed a 3-day delay in onset of disease. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-107589 | BIO 5192 BIO5192 | 327613-57-0 | 5 mg | 2200元 |
| 2026/09/15 | HY-107589 | BIO 5192 BIO5192 | 327613-57-0 | 10 mg | 3500元 |