| Company Name: |
SPIRO PHARMA |
| Tel: |
|
| Email: |
eric_feng1954@126.com |
PF4455242 hydrochloride manufacturers
- PF-4455242 HCl
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- $1980.00
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2026-05-11
- CAS:1322001-35-3
- Purity: 99.59%
- Supply Ability: 10g
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| | PF4455242 hydrochloride Basic information |
| Product Name: | PF4455242 hydrochloride | | Synonyms: | PF 04455242 hydrochloride;PF 4455242 hydrochloride;PF-04455242 (hydrochloride);PF04455242 hydrochloride;PF4455242 hydrochloride;PF-4455242 hydrochloride;2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride;N-(2-Methylpropyl)-2′-(1-pyrrolidinylsulfonyl)-[1,1′-biphenyl]-4-methanamine hydrochloride | | CAS: | 1322001-35-3 | | MF: | C21H29ClN2O2S | | MW: | 408.99 | | EINECS: | | | Product Categories: | | | Mol File: | 1322001-35-3.mol |  |
| | PF4455242 hydrochloride Chemical Properties |
| storage temp. | room temp | | solubility | DMSO: soluble5mg/mL (clear solution, warmed) | | form | powder | | color | white to beige | | InChI | 1S/C21H28N2O2S.ClH/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23;/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3;1H | | InChIKey | WRNZYMZEVIVCFL-UHFFFAOYSA-N | | SMILES | Cl.CC(C)CNCc1ccc(cc1)-c2ccccc2S(=O)(=O)N3CCCC3 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | PF4455242 hydrochloride Usage And Synthesis |
| Uses | PF-4455242 hydrochloride is a selective, short-acting antagonist of the κ-opioid receptor, exhibiting potential analgesic effects. PF-4455242 hydrochloride has been identified through a strategy utilizing parallel chemistry and physicochemical property design. PF-4455242 hydrochloride demonstrated confirmed potency and selectivity in the tail-flick analgesia model. | | Biological Activity | PF-4455242 is a selective k opioid receptor (KOR) antagonist with 20-fold selectivity for kappa over mu receptors (k Ki = 3 nM, μ Ki =64 nM). PF-4455242 is orally active, has good brain penetration in rats and was able to block the effects of the kappa agonist U50488. Studies indicate th at k blockade has afforded antidepressant activity in several animal models. PF-4455242 has been in phase I clinical trials for trial for bipolar depression. | | References | [1] Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242) |
| | PF4455242 hydrochloride Preparation Products And Raw materials |
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