1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- manufacturers
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| | 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Basic information |
| | 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Chemical Properties |
| Boiling point | 423.2±30.0 °C(Predicted) | | density | 1.040±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 140 mg/mL (506.57 mM) | | pka | 9.76±0.31(Predicted) | | form | Solid | | color | Yellow to orange |
| | 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Usage And Synthesis |
| Uses | (E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2]. | | in vivo | (E)-[6]-Dehydroparadol (compound 19) (5 μM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos[2]. | | References | [1] Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57(5):865-76. DOI:10.1002/mnfr.201200708
[2] Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54. DOI:10.1016/j.freeradbiomed.2016.03.026 |
| | 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- Preparation Products And Raw materials |
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