| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:NF-κB-IN-1
CAS:1227098-15-8
Purity:98% Package:2mg Remarks:S23302
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1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- manufacturers
- NF-κB-IN-1
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- $169.00 / 1mg
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2025-12-23
- CAS:1227098-15-8
- Min. Order:
- Purity: 99.29%
- Supply Ability: 10g
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| | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Basic information |
| Product Name: | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- | | Synonyms: | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-;AC17 NF-κB-IN-1;NF-κB-IN-1;NF-kB-IN-1(AC17);(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione;pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB;T63;NF-κB-IN-1, 10 mM in DMSO | | CAS: | 1227098-15-8 | | MF: | C31H30O8 | | MW: | 530.57 | | EINECS: | | | Product Categories: | | | Mol File: | 1227098-15-8.mol | ![1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Structure](CAS/20210111/GIF/1227098-15-8.gif) |
| | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Chemical Properties |
| Boiling point | 732.0±60.0 °C(Predicted) | | density | 1.233±0.06 g/cm3(Predicted) | | pka | 9.27±0.31(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Usage And Synthesis |
| Uses | NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1]. | | Biological Activity | NF-κB-IN-1, a 4-arylene curcumin analog, is a potent NF-κB signaling pathway inhibitor. It directly inhibits IKK to block NF-κB activation. It can effectively inhibit the viability of lung cancer cells and attenuate the clonal activity of A549 cells. | | in vitro | NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI 50 s of 0.72, 0.07, 0.13, and 0.16 μM, respectively. | | target | | | References | [1] Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73. DOI:10.1021/jm1004545 |
| | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Preparation Products And Raw materials |
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