- S14161
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- $170.00
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2026-05-11
- CAS:883046-50-2
- Purity:
- Supply Ability: 10g
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| Product Name: | S14161 | | Synonyms: | S14161;8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran;SAG Analog (LowTox);2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-;S14161, Apoptotic agent | | CAS: | 883046-50-2 | | MF: | C17H14FNO4 | | MW: | 315.2957632 | | EINECS: | | | Product Categories: | | | Mol File: | 883046-50-2.mol |  |
| | S14161 Chemical Properties |
| Boiling point | 456.2±45.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | color | Yellow | | InChI | 1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3 | | InChIKey | BFZXDHIUPNWOMT-UHFFFAOYSA-N | | SMILES | FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Skin Irrit. 2 |
| | S14161 Usage And Synthesis |
| Description | D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day. | | Uses | S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. | | Uses | D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.[Cayman Chemical] | | storage | +4°C | | References | [1] XINLIANG MAO. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.[J]. Blood, 2011: 1986-1997. DOI: 10.1182/blood-2010-05-284810 |
| | S14161 Preparation Products And Raw materials |
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