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HS-173

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HS-173 manufacturers

  • HS-173
  • HS-173 pictures
  • $30.00
  • 2026-07-27
  • CAS:1276110-06-5
  • Purity: 99.33%
  • Supply Ability: 10g
  • HS-173
  • HS-173 pictures
  • $2.00
  • 2019-07-06
  • CAS:1276110-06-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
HS-173 Basic information
Product Name:HS-173
Synonyms:HS 173;HS173;CS-1007;ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate;6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester HS-173;HS-173;6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;HS-173, 98%, a novel PI3K inhibitor;Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-[5-[(phenylsulfonyl)amino]-3-pyridinyl]-, ethyl ester
CAS:1276110-06-5
MF:C21H18N4O4S
MW:422.46
EINECS:
Product Categories:Inhibitors
Mol File:1276110-06-5.mol
HS-173 Structure
HS-173 Chemical Properties
Melting point >193°C (dec.)
density 1.38±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly)
pka6.84±0.40(Predicted)
form Solid
color Grey to Brown
InChIInChI=1S/C21H18N4O4S/c1-2-29-21(26)19-13-23-20-9-8-15(14-25(19)20)16-10-17(12-22-11-16)24-30(27,28)18-6-4-3-5-7-18/h3-14,24H,2H2,1H3
InChIKeySEKOTFCHZNXZMM-UHFFFAOYSA-N
SMILESC12=NC=C(C(OCC)=O)N1C=C(C1=CC(NS(C3=CC=CC=C3)(=O)=O)=CN=C1)C=C2
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
HS-173 Usage And Synthesis
DescriptionHS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM. It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively. HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases. It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.
UsesHS-173 is a potent PI3Kα inhibitor with anticancer activity.
in vitrohs-173 inhibited the pi3k signaling pathway, and showed anti-proliferative effects on cancer cells. also, hs-173 induced cell cycle arrest at the g2/m phase and apoptosis. in addition, hs-173 decreased the expression hif-1a and vegf which play an important role in angiogenesis. this effect was confirmed by the suppression of tube formation and migration assay in vitro [1].
in vivohs-173 diminished blood vessel formation in the matrigel plug assay in mice. these results suggest that hs-173 has potent anti-angiogenic activity in vivo [1].
targetPI3Kα
IC 50PI3Kα: 0.8 nM (IC50)
references[1] lee h, jung kh, jeong y, hong s, hong ss. hs-173, a novel phosphatidylinositol 3-kinase (pi3k) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. cancer lett. 2013 jan 1;328(1):152-9.
HS-173 Preparation Products And Raw materials
Tag:HS-173(1276110-06-5) Related Product Information
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