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| | 2-(Boc-aMino)-4-Methylthiophene Basic information |
| Product Name: | 2-(Boc-aMino)-4-Methylthiophene | | Synonyms: | 2-(Boc-aMino)-4-Methylthiophene;tert-butyl N-(4-methylthiophen-2-yl)carbamate;tert-Butyl (4-methylthiophen-2-yl)carbamate;Carbamic acid, (4-methyl-2-thienyl)-, 1,1-dimethylethyl ester;Carbamic acid, N-(4-methyl-2-thienyl)-, 1,1-dimethylethyl ester | | CAS: | 887475-43-6 | | MF: | C10H15NO2S | | MW: | 213.3 | | EINECS: | | | Product Categories: | | | Mol File: | 887475-43-6.mol |  |
| | 2-(Boc-aMino)-4-Methylthiophene Chemical Properties |
| Boiling point | 254.6±28.0 °C(Predicted) | | density | 1.157±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 13.63±0.70(Predicted) | | Appearance | Off-white to brown Solid |
| | 2-(Boc-aMino)-4-Methylthiophene Usage And Synthesis |
| Synthesis | General procedure for the synthesis of tert-butyl (4-methylthiophen-2-yl)carbamate from 4-methyl-2-thiophenecarboxylate (1.00 g, 7.03 mmol) and tert-butanol: 4-methyl-2-thiophenecarboxylate (1.00 g, 7.03 mmol), diphenylphosphoryl azide (1.94 g, 7.03 mmol) and triethylamine (0.98 mL. 7.03 mmol) were dissolved in tert-butanol (20 mL) and heated to reflux for 5 hours. Upon completion of the reaction, confirmation was monitored by thin layer chromatography (unfolding agent: dichloromethane/hexane). The reaction mixture was cooled to room temperature, poured into water and extracted with ether (3 x 20 mL). The ether extracts were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a beige solid. Purification by silica gel column chromatography (eluent: hexane/dichloromethane) afforded the target compound tert-butyl (4-methylthiophen-2-yl)carbamate (0.96 g, yield 64%) as a white solid.1H-NMR (400 MHz, DMSO-d6) δ 6.42 (s, 1H), 6.35 (d, 1H), 1.46 (s, 9H). | | References | [1] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 151
[2] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 77
[3] Patent: WO2013/78468, 2013, A1. Location in patent: Paragraph 0800 |
| | 2-(Boc-aMino)-4-Methylthiophene Preparation Products And Raw materials |
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