替诺福韦阿拉芬酰胺富马酸酯 CAS#: 379270-38-9

替诺福韦阿拉芬酰胺富马酸酯

生物活性靶点体外研究体内研究用途与合成方法 MSDS 替诺福韦阿拉芬酰胺富马酸酯价格(试剂级) 上下游产品信息

中文名称	替诺福韦阿拉芬酰胺富马酸酯
中文同义词	GS7340单盐;泰诺福韦艾拉酚胺富马酸盐;替诺福韦艾拉酚胺富马酸盐(1:1);替诺福韦艾拉酚胺富马酸单盐;富马酸GS-7340;GS 7340 富马酸盐;泰诺福韦艾拉酚胺半盐;替诺福韦艾拉酚胺富马酸盐[单盐]
英文名称	Tenofovir alafenamide fumarate
英文同义词	Tenofovir alafenamide-19;Tenofovir impurity 42/Tenofovir Alafenamide Fumarate/isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate fumarate;tenofovir alafenamide fumarate (TAF);vemlidy;GS-7340 (fuMarate);L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (1:1);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-llanine 1-methylethyl ester (2E)-2-butenedioate (1:1);Tenofovir alafenamide : fumarate = 1:1)
CAS号	379270-38-9
分子式	C21H29N6O5P.C4H4O4
分子量	592.54
EINECS号	223-388-5
相关类别	原料药;抗病毒药
Mol文件	379270-38-9.mol
结构式

替诺福韦阿拉芬酰胺富马酸酯性质

熔点	119.7-121.1 °C
储存条件	under inert gas (nitrogen or Argon) at 2-8°C
溶解度	DMSO:68.0(最大浓度 mg/mL);114.56(最大浓度 mM) 乙醇:100.0(最大浓度 mg/mL);168.48(最大浓度 mM) 水:17.5(最大浓度 mg/mL);29.48(最大浓度 mM)
形态	粉末
颜色	白色至米白色
InChIKey	MEJAFWXKUKMUIR-GQDWUREHNA-N
SMILES	C(/C(=O)O)=C\C(=O)O.C(N1C=NC2=C(N=CN=C12)N)[C@@H](C)OCP(=O)(N[C@@H](C)C(=O)OC(C)C)OC1C=CC=CC=1 \|&1:19,26,r\|

替诺福韦阿拉芬酰胺富马酸酯用途与合成方法

生物活性

Tenofovir alafenamide fumarate (GS-7340 fumarate) 是 Tenofovir 的前体，Tenofovir 是一种 HIV-1 核苷酸逆转录酶抑制剂。

靶点

HIV-1, NRTIs

体外研究

Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC ₅₀ varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC ₅₀ s range from 0.1 to 12 nM, with a mean EC ₅₀ of 3.5 nM compared to a mean EC ₅₀ of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC ₅₀ s are 1.8 nM for TAF and 6.4 nM for AZT.

体内研究

Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF).

安全信息

MSDS信息

替诺福韦阿拉芬酰胺富马酸酯价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/06/05	HY-15232A	替诺福韦阿拉芬酰胺富马酸酯 Tenofovir alafenamide fumarate	379270-38-9	5 mg	500元
2026/06/05	HY-15232A	替诺福韦阿拉芬酰胺富马酸酯 Tenofovir alafenamide fumarate	379270-38-9	10 mg	650元

替诺福韦阿拉芬酰胺富马酸酯