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Product Name:8α-Tigloyloxyhirsutinolide 13-O-acetate
CAS:83182-58-5
Purity:>97.0% Package:5mg Remarks:BBP03715
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Product Name:8α-Tigloyloxyhirsutinolide 13-O-acetate
CAS:83182-58-5
Purity:95%+ Package:根据客户需求包装
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Product Name:8α-Tigloyloxyhirsutinolide 13-O-acetate
CAS:83182-58-5
Purity:95% Package:5mg-1g Remarks:Item No.: ALB-RS-4319
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Product Name:8alpha-Tigloyloxyhirsutinolide 13-O-acetate
CAS:83182-58-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | 8α-Tigloyloxyhirsutinolide 13-O-acetate Basic information |
| Product Name: | 8α-Tigloyloxyhirsutinolide 13-O-acetate | | Synonyms: | 8α-Tigloyloxyhirsutinolide 13-O-acetate;8alpha-Tigloyloxyhirsutinolide 13-O-acetate;2-Butenoic acid, 2-methyl-, (4S,6R,7S,10R,11E)-3-[(acetyloxy)methyl]-2,4,5,6,7,8,9,10-octahydro-7-hydroxy-6,10-dimethyl-2-oxo-7,10-epoxycyclodeca[b]furan-4-yl ester, (2E)-;8α-Tigloyloxyhirsutinolide13-O-acetate;[(1R,2E,8S,10R,11S)-6-(Acetyloxymethyl)-11-hydroxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] (E)-2- methylbut-2-enoate | | CAS: | 83182-58-5 | | MF: | C22H28O8 | | MW: | 420.45 | | EINECS: | | | Product Categories: | | | Mol File: | 83182-58-5.mol |  |
| | 8α-Tigloyloxyhirsutinolide 13-O-acetate Chemical Properties |
| Boiling point | 589.6±50.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | pka | 12.51±0.70(Predicted) |
| | 8α-Tigloyloxyhirsutinolide 13-O-acetate Usage And Synthesis |
| Uses | 8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo[1][2]. | | in vivo | 8α-Tigloyloxyhirsutinolide 13-O-acetate (5mg/kg, Oral gavage, 5 times per week for 75 days) suppresses tumor growth in mice[1]. | Animal Model: | Five-week-old female athymic nude mice (injected subcutaneously in the right flank area with MDA-MB-468 cells in 100μL PBS) | | Dosage: | 5mg/kg | | Administration: | Oral gavage, every day, 5 times per week for 75 days | | Result: | Inhibited MDA-MB-468 xenografts growth in mice, with reduced pY705-STAT3, G6PD, TrxR1, and GSH levels. |
| | IC 50 | STAT3; Bcl-2; Bcl-xL; Mcl-1 | | References | [1] Zhu Y, et al. Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo. Cell Death Dis. 2022 Dec 6;13(12):1022. DOI:10.1038/s41419-022-05477-2
[2] A Bardón, et al. Glaucolides and related sesquiterpene lactones fromVernonia nudiflora and Chrysolaena propinqua. Phytochemistry, 1992, 31(2):609-613. |
| | 8α-Tigloyloxyhirsutinolide 13-O-acetate Preparation Products And Raw materials |
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