| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
5HPP-33 manufacturers
- 5HPP-33
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- $2500.00
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2026-05-11
- CAS:105624-86-0
- Purity:
- Supply Ability: 10g
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| | 5HPP-33 Basic information |
| Product Name: | 5HPP-33 | | Synonyms: | 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione;5HPP-33;5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-[2,6-bis(1-methylethyl)phenyl]-5-hydroxy- | | CAS: | 105624-86-0 | | MF: | C20H21NO3 | | MW: | 323.39 | | EINECS: | | | Product Categories: | | | Mol File: | 105624-86-0.mol |  |
| | 5HPP-33 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >20mg/mL | | form | solid | | color | white to off-white | | InChI | 1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3 | | InChIKey | LAKWINYVWJPHQW-UHFFFAOYSA-N | | SMILES | CC(C)c1cccc(C(C)C)c1N2C(=O)c3ccc(O)cc3C2=O |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1 |
| | 5HPP-33 Usage And Synthesis |
| Description | 5HPP-33 is a compound that was initially identified for its anti-angiogenic properties. It suppresses microtubule dynamics and depolymerises microtubule network by binding at vinblastine site on tubulin. It is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. | | Uses | 5HPP-33 is a thalidomide derivative with cell-proliferation inhibitory properties. | | Biochem/physiol Actions | 5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM). |
| | 5HPP-33 Preparation Products And Raw materials |
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