| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- HS-27
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- $92.00
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2026-08-30
- CAS:1562024-11-6
- Purity: 98.56%
- Supply Ability: 10g
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| Product Name: | Hs 27 | | Synonyms: | Hs 27;HS27;HS-27;HS 27;Benzamide, 2-[[21-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-21-thioxo-4,7,10,13,16-pentaoxa-20-azaheneicos-1-yl]amino]-4-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)-;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thio,HS-27;1562024-11-7;HS27,HS 27;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide,HS-27;2-((1-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide | | CAS: | 1562024-11-6 | | MF: | C52H60N6O12S | | MW: | 993.13 | | EINECS: | | | Product Categories: | | | Mol File: | 1562024-11-6.mol |  |
| | Hs 27 Chemical Properties |
| Boiling point | 1095.1±75.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | -196°C | | solubility | DMSO: 125 mg/mL (125.86 mM) | | pka | 9.33±0.20(Predicted) | | form | Solid | | color | Yellow to orange |
| | Hs 27 Usage And Synthesis |
| Uses | HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer[1]. | | Biological Activity | HS-27, a fluorescent Hsp90 inhibitor, detects Hsp90 expression on the surface of intact tissue specimens. It consists of the core elements of SNX-5422, an Hsp90 inhibitor linked via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC) that binds to peripherally expressed Hsp90 combine. | | in vitro | HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. | | target | | | IC 50 | HSP90 | | References | [1] Crouch BT, et al. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Sci Rep. 2019 Mar 5;9(1):3461. DOI:10.1038/s41598-019-40252-y |
| | Hs 27 Preparation Products And Raw materials |
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