PYRIDOSTATIN HYDROCHLORIDE
| 中文名称 | PYRIDOSTATIN HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 PYRIDOSTATIN HYDROCHLORIDE;PYRIDOSTATIN盐酸盐;4-(2-氨基乙氧基)-N2,N6-双(4-(2-氨基乙氧基)喹啉-2-基)吡啶-2,6-二甲酰胺五盐酸盐;化合物:Pyridostatin hydrochloride CAS:1781882-65-2;化合物：Pyridostatin hydrochloride CAS:1781882-65-2 |
| 英文名称 | Pyridostatin hydrochloride |
| 英文同义词 | Pyridostatin hydrochloride;Pyridostatin HCl;RR-82 hydrochloride;4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide pentahydrochloride |
| CAS号 | 1781882-65-2 |
| 分子式 | C31H33ClN8O5 |
| 分子量 | 633.11 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1781882-65-2.mol |
| 结构式 |  |
PYRIDOSTATIN HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO: 2 mg/mL, clear |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water: 50 mg/mL (64.19 mM) |
| InChIKey | VGHSATQVJCTKEF-UHFFFAOYSA-N |
| SMILES | NCCOc1cc(nc(c1)C(=O)Nc4nc5c(c(c4)OCCN)cccc5)C(=O)Nc2nc3c(c(c2)OCCN)cccc3 |
Pyridostatin (RR82) hydrochloride 是一种高选择性的 G-quadruplex DNA 稳定剂 (Kd=490 nM)。Pyridostatin hydrochloride 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin hydrochloride 靶向原癌基因 Src。Pyridostatin hydrochloride 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。
Kd: 490 nM (G-quadruplexe)
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.
Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Cell Viability Assay
| Cell Line: | Over 60 different cancer cell lines |
| Concentration: | 10 μM |
| Incubation Time: | 48 hours |
| Result: | Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 5mg | 1120元 |
| 2026/06/05 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 10mg | 1480元 |