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SIB 1553A hydrochloride manufacturers
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| | SIB 1553A hydrochloride Basic information |
| Product Name: | SIB 1553A hydrochloride | | Synonyms: | SIB 1553A hydrochloride;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride;SIB 1553A Hyrdrochloride;(±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol;SIB 1553A,SIB1553A;SIB 1553A hydrochloride, nAChR agonist;4-((2-(1-Methylpyrrolidin-2-yl)ethyl)thio)phenol hydrochloride | | CAS: | 191611-89-9 | | MF: | C13H20ClNOS | | MW: | 273.82 | | EINECS: | | | Product Categories: | | | Mol File: | 191611-89-9.mol |  |
| | SIB 1553A hydrochloride Chemical Properties |
| Melting point | 149-151°C | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Water Solubility | Soluble to 100 mM in water |
| | SIB 1553A hydrochloride Usage And Synthesis |
| Description | SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors. Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals. | | Uses | SIB 1553A hyrdrochloride is a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors (nAChR). | | in vivo | SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3]. | Animal Model: | Male Sprague-Dawley rats (200-250 g)[3] | | Dosage: | 1, 2, 4, 10, 20 and 40 mg/kg | | Administration: | s.c. | | Result: | Induced hippocampal ACh release. |
| | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] J S SCHNEIDER. The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 306 1: 401-406. DOI: 10.1124/jpet.103.051912
[3] TERRY A, RISBROUGH V, BUCCAFUSCO J, et al. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 264 1: 0. DOI: 10.1124/jpet.301.1.284 |
| | SIB 1553A hydrochloride Preparation Products And Raw materials |
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