- SIB-1757
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- $48.00
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2026-07-14
- CAS:31993-01-8
- Purity: 98.49%
- Supply Ability: 10g
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| | SIB 1757 Basic information |
| Product Name: | SIB 1757 | | Synonyms: | SIB 1757;SIB-1757 6-METHYL-2-(PHENYLAZO)-3-PYRIDINOL;6-METHYL-2-(PHENYLAZO)-3-PYRIDINOL;6-Methyl-2-[(E)-phenyldiazenyl]pyridin-3-ol;(E)-6-Methyl-2-(phenyldiazenyl)pyridin-3-ol;6-methyl-2-[(E)-phenyldiazenyl]pyridin-3;3-Pyridinol, 6-methyl-2-(2-phenyldiazenyl)-;SIB-1757,mGluR,SIB1757,Metabotropic glutamate receptors,inhibit,Inhibitor,SIB 1757 | | CAS: | 31993-01-8 | | MF: | C12H11N3O | | MW: | 213.24 | | EINECS: | | | Product Categories: | Glutamate receptor | | Mol File: | 31993-01-8.mol |  |
| | SIB 1757 Chemical Properties |
| storage temp. | Store at RT | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | crystalline | | color | red | | InChI | 1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+ | | InChIKey | LOCPVWIREQIGNQ-CCEZHUSRSA-N | | SMILES | Cc1ccc(O)c(\N=N\c2ccccc2)n1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | SIB 1757 Usage And Synthesis |
| Uses | SIB 1757 is an antagonist for mGluR-5. | | Definition | ChEBI: 6-methyl-2-(phenylhydrazinylidene)-3-pyridinone is a member of phenylhydrazines. | | Biological Activity | A highly selective antagonist for the mGlu 5 metabotropic glutamate receptor subtype; displays an IC 50 value of 0.4 μ M at hmGlu 5 compared with > 30 μ M at hmGlu 1b , hmGlu 2 , hmGlu 4 , hmGlu 6 , hmGlu 7 and hmGlu 8 . | | in vivo | SIB-1757 (20 mg/kg, i.p.) reduces the Acetaminophen (HY-66005) induced increased expression and activity of liver iNOS in mice[2].
SIB-1757 (intraplantar injection of 100 μg, or s.c. injection of 20 mg/kg) reverses spinal nerve ligation-induced thermal hyperalgesia in rats[3].
| | IC 50 | human mGluR5: 0.4 μM (IC50) |
| | SIB 1757 Preparation Products And Raw materials |
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