| Company Name: |
Musechem |
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
TGR-1202 (hydrochloride) manufacturers
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| | TGR-1202 (hydrochloride) Basic information |
| Product Name: | TGR-1202 (hydrochloride) | | Synonyms: | TGR-1202 (hydrochloride);Umbralisib (TGR-1202) HCl;TGR-1202 hydrochloride(Umbralisib);RP 5264 hydrochloride;RP5264 hydrochloride;RP-5264 hydrochloride;RP5264 HYDROCHLORIDE; TGR1202 HYDROCHLORIDE; TGR 1202 HYDROCHLORIDE; RP-5264 HYDROCHLORIDE; RP 5264 HYDROCHLORIDE;Umbralisib (TGR-1202) hydrochloride | | CAS: | 1532533-78-0 | | MF: | C31H25ClF3N5O3 | | MW: | 608.02 | | EINECS: | | | Product Categories: | | | Mol File: | 1532533-78-0.mol |  |
| | TGR-1202 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: ≥ 150 mg/mL (246.71 mM); Water: < 0.1 mg/mL (insoluble) | | form | Solid | | color | White to off-white |
| | TGR-1202 (hydrochloride) Usage And Synthesis |
| Uses | 2-[(1S)-1-[4-Amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one Hydrochloride (1:1) is a drug candidate. It is used in the preparation of 1H-Pyrazolo[3,4-d]pyrimidine derivatives as selective PI3K delta inhibitors for treatment of autoimmune and inflammatory disorders, and proliferative diseases such as cancer. | | in vivo | Umbralisib hydrochloride (150 mg/kg, daily p.o.) significantly shrinks the tumors by day 25 in a subcutaneous xenograft model of T-cell acute lymphoblastic leukemia (T-ALL) in NOD/SCID mice using the MOLT-4 cell line[4]. | | IC 50 | PI3Kδ: 22.2 nM (EC50); PI3Kδ: 6.2 nM (Kd); PI3Kγ: 1400 nM (Kd); PI3Kβ: >10000 nM (Kd); PI3Kα: >10000 nM (Kd) |
| | TGR-1202 (hydrochloride) Preparation Products And Raw materials |
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