- Sodium dichloroacetate
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- $10.00 / 1KG
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2025-10-21
- CAS:2156-56-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Sodium dichloroacetate
-
- $8.00 / 1KG
-
2025-09-25
- CAS:2156-56-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
Related articles - What is Sodium dichloroacetate?
- Sodium Dichloroacetate is the sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion i....
- Dec 30，2019
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| | Sodium dichloroacetate Basic information | | Uses |
| Product Name: | Sodium dichloroacetate | | Synonyms: | dichloroacetate,sodiumsalt;dichloro-aceticacisodiumsalt;dichloroctansodny;Sodiumdichloracetate;NATRIUMDICHLORACETAT;SDA;SODIUM DICHLOROACETATE;erlcyiuanna | | CAS: | 2156-56-1 | | MF: | C2H3Cl2NaO2 | | MW: | 152.93 | | EINECS: | 218-461-3 | | Product Categories: | | | Mol File: | 2156-56-1.mol |  |
| | Sodium dichloroacetate Chemical Properties |
| Melting point | 198 °C (dec.) (lit.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Methanol (Slightly), Water (Slightly) | | form | Powder | | color | White | | PH | 6.0 to 8.5(50g/L, 25 ℃) | | Water Solubility | soluble in cold water | | Sensitive | Moisture Sensitive | | Stability: | Hygroscopic | | InChI | InChI=1S/C2H2Cl2O2.Na.H/c3-1(4)2(5)6;;/h1H,(H,5,6);; | | InChIKey | LUPNKHXLFSSUGS-UHFFFAOYSA-M | | SMILES | C(Cl)(Cl)C(=O)O.[NaH] | | CAS DataBase Reference | 2156-56-1(CAS DataBase Reference) | | EPA Substance Registry System | Sodium dichloroacetate (2156-56-1) |
| | Sodium dichloroacetate Usage And Synthesis |
| Uses | Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic. Recent studies had found that DCA acts as a potential vasoprotective agent by inhibiting PDK2 and reducing coronary endarterium proliferation. Further, DCA promotes brain regeneration after cerebral ischemia, which indicates that DCA might play an important role in VD.
| | Chemical Properties | white powder | | Uses | Treatment of neurologic injury (pyruvate dehydrogenase activator). | | Uses | Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase. | | Brand name | Ceresine (Cypros). | | General Description | Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity. | | Biological Activity | Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo . | | Synthesis | General procedure for the synthesis of sodium dichloroacetate from dichloroacetic acid: Cl2CHCO2H (135 μL, 1.64 mmol) was dissolved in H2O (2 mL), treated with 1.00 M NaOH (1.60 mL, 1.60 mmol), and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, the volatiles were removed under vacuum to give a pale yellow residue. The residue was suspended in acetone, the suspension was filtered, the resulting colorless solid was washed with acetone and finally dried under vacuum. Yield: 227 mg, 96% yield. | | storage | Desiccate at RT | | References | [1] Journal of Organometallic Chemistry, 2018, vol. 869, p. 201 - 211 |
| | Sodium dichloroacetate Preparation Products And Raw materials |
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