MK-2 INHIBITOR III (COMPOUND 16)
| 中文名称 | MK-2 INHIBITOR III (COMPOUND 16) |
|---|---|
| 中文同义词 | MK-2 INHIBITOR III H2O;化合物MK-2 INHIBITOR III;2-(2-(喹啉-3-基)吡啶-4-基)-6,7-二氢-1H-吡咯并[3,2-C]吡啶-4(5H)-酮水合物;化合物MK-2 INHIBITOR III,10 MM DMSO 溶液 |
| 英文名称 | MK-2 Inhibitor III |
| 英文同义词 | MK-2 Inhibitor III;2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate;MK-2 INHIBITOR III (COMPOUND 16);MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem;MK2-IN-3 hydrate;2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate;Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2;MK2-IN-3 hydrate, 10 mM in DMSO |
| CAS号 | 1186648-22-5 |
| 分子式 | C21H18N4O2 |
| 分子量 | 358.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1186648-22-5.mol |
| 结构式 |  |
MK-2 INHIBITOR III (COMPOUND 16) 性质
| 熔点 | >255°C (dec.) |
|---|---|
| 储存条件 | +2C to +8C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 淡黄色固体 |
| 颜色 | 灰白色至浅黄色 |
| InChIKey | NIKCVKMHGQQSRN-UHFFFAOYSA-N |
| SMILES | [nH]1c2c(cc1c3cc(ncc3)c4cnc5c(c4)cccc5)C(=O)NCC2.O |
MK2-IN-3 hydrate (compound 16) 是一种具有口服活性的，选择性的，ATP 竞争性的 MAPKAP-K2 (MK-2) 抑制剂，IC50 值为 0.85 nM。MK2-IN-3 hydrate 对 MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) 以及 CDK2, JNK2, IKK2, MSK1, and MSK2 也具有选择性。
IC50: 0.85 nM (MK-2), 0.21 μM (MK-3), 0.081 μM (MK-5), 3.44 μM (ERK2), 5.7 μM (MNK1)
MK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC 50 of 4.4 μM.
安全信息
| WGK Germany | WGK 1 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-112457 | MK-2 INHIBITOR III (COMPOUND 16) MK2-IN-3 hydrate | 1186648-22-5 | 1 mg | 923元 |
| 2026/06/05 | HY-112457 | MK-2 INHIBITOR III (COMPOUND 16) MK2-IN-3 hydrate | 1186648-22-5 | 5 mg | 1788元 |