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| | Abacavir (sulfate) Basic information |
| Product Name: | Abacavir (sulfate) | | Synonyms: | Abacavir monosulfate;4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-(1S,4R)-2-cyclopentene-1-methanolsulfate | | CAS: | 216699-07-9 | | MF: | C14H20N6O5S | | MW: | 384.41 | | EINECS: | | | Product Categories: | | | Mol File: | 216699-07-9.mol |  |
| | Abacavir (sulfate) Chemical Properties |
| solubility | DMSO: 0.15 mg/ml; PBS (pH 7.2): 1 mg/ml | | form | A crystalline solid |
| | Abacavir (sulfate) Usage And Synthesis |
| Uses | Abacavir (sulfate) is an antiviral analog of guanosine, inhibiting the reverse transcriptase of HIV type 1 with an IC50 value of 5.3 μM. This blocks retroviral replication, which assists in retroviral therapy. Abacavir (sulfate), commonly used in combination with other antiretroviral compounds, has been associated with a diagnosis of hypersensitivity syndrome.[Cayman Chemical] | | in vivo | Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3]. | Animal Model: | Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2] | | Dosage: | 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg | | Administration: | Intrascrotal or oral administration for 4 h | | Result: | Dose-dependently promoted thrombus formation. |
| Animal Model: | NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3] | | Dosage: | 50 mg/kg/d with 0.1 mg/kg/d Decitabine | | Administration: | Intraperitoneal injection, daily for 14 days | | Result: | Inhibited tumor growth and enhanced mouse survival. |
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| | Abacavir (sulfate) Preparation Products And Raw materials |
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