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| | N-Arachidonoyl Dopamine-d8 Exclusive Basic information |
| Product Name: | N-Arachidonoyl Dopamine-d8 Exclusive | | Synonyms: | N-Arachidonoyl Dopamine-d8 Exclusive;(5Z,8Z,11Z,14Z)-5,6,8,9,11,12,14,15-octadeuterio-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide | | CAS: | 1159908-42-5 | | MF: | C28H33D8NO3 | | MW: | 447.679 | | EINECS: | | | Product Categories: | | | Mol File: | 1159908-42-5.mol |  |
| | N-Arachidonoyl Dopamine-d8 Exclusive Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: Colloidal suspension @ 100 μg/,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,Ethanol:PBS (pH 7.2)(1:1): 100 μg/ml (colloidal suspensio |
| | N-Arachidonoyl Dopamine-d8 Exclusive Usage And Synthesis |
| Uses | N-Arachidonyldopamine-d8 is the deuterium labeled N-Arachidonyldopamine[1]. | | Biological Activity | N-Arachidonoyl dopamine-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of N-arachidonoyl dopamine by GC- or LC-mass spectrometry. Several different arachidonoyl amino acids, including NADA, have been isolated and characterized from bovine brain.1 NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective cannabinoid agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA).2 NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 μM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA's endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.3 | | References | 1.Huang, S.M., Bisogno, T., Petros, T.J., et al.Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits painThe Journal of Biological Chemisty276(46)42639-42644(2001)
2.Bisogno, T., Melck, D., Bobrov, M.Y., et al.N-acyl-dopamines: Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivoBiochem. J.351(Pt 3)817-824(2001)
3.Randall, M., and Maxey, K.M.Personal Communication(2003) |
| | N-Arachidonoyl Dopamine-d8 Exclusive Preparation Products And Raw materials |
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