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| | N-Arachidonoyl-L-Serine-d8 Basic information |
| | N-Arachidonoyl-L-Serine-d8 Chemical Properties |
| Boiling point | 607.588±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.027±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 20 mg/ml
DMSO: 20 mg/ml
Ethanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml | | pka | 3.258±0.10(predicted) |
| | N-Arachidonoyl-L-Serine-d8 Usage And Synthesis |
| Uses | N-Arachidonoyl-L-serine-d8 is an isotopic analogue of N-Arachidonoyl-L-serine (A765110), which is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and in vivo in mice model of traumatic brain injury. | | References | [1] T BISOGNO. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.[J]. Biochemical Journal, 2000, 351 Pt 3: 817-824.
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] GARRY MILMAN. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 2428-2433. DOI: 10.1073/pnas.0510676103
[4] SATOKO NAOE. Characterization of Lipid Profiles after Dietary Intake of Polyunsaturated Fatty Acids Using Integrated Untargeted and Targeted Lipidomics[J]. Metabolites, 2019. DOI: 10.3390/metabo9100241 |
| | N-Arachidonoyl-L-Serine-d8 Preparation Products And Raw materials |
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