那他珠单抗
| 中文名称 | 那他珠单抗 |
|---|---|
| 中文同义词 | NATALIZUMAB ( 那他珠单抗 );那他珠单抗;NATALIZUMAB单抗;Natalizumab (anti-ITGA4) |
| 英文名称 | Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer |
| 英文同义词 | Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer;Natalizumab-Tysabri;Research Grade Natalizumab(DHC98801);inhibit,Inhibitor,Natalizumab,Integrin;Research Grade Natalizumab;Natalizumab (anti-ITGA4) |
| CAS号 | 189261-10-7 |
| 分子式 | C40H55N7O11S |
| 分子量 | 841.97 |
| EINECS号 | |
| 相关类别 | 化学试剂 |
| Mol文件 | 189261-10-7.mol |
| 结构式 |  |
那他珠单抗 性质
| 储存条件 | Store at 4°C, do not freeze |
|---|---|
| 形态 | 液体 |
| 颜色 | 无色至浅黄 |
那他珠单抗是一种重组的人源化单克隆抗体，与 α4β1-整联蛋白 (α4β1-integrin) 结合并阻断其与血管细胞粘附分子 1 (VCAM-1) 的相互作用。那他珠单抗可用于复发缓解型多发性硬化症和克罗恩氏病的研究， 也可阻止淋巴细胞进入中枢神经系统，从而防止急性脱髓鞘复发。
Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.
Natalizumab binds rapidly and with high affinity to α4-integrin. Maximal binding (≥80% saturation), measured in vitro on isolated lymphocyte membranes, occurred 24 hours after intravenous (IV) doses of natalizumab 1 mg/kg to 6 mg/kg.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108831A | 那他珠单抗 Natalizumab (Anti-CD49d) | 189261-10-7 | 5 mg | 2400元 |
| 2026/06/05 | HY-108831A | 那他珠单抗 Natalizumab (Anti-CD49d) | 189261-10-7 | 10 mg | 3900元 |