WRR483 manufacturers
- WRR-483
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- $1520.00
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2026-05-11
- CAS:1076088-50-0
- Purity:
- Supply Ability: 10g
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| Product Name: | WRR483 | | Synonyms: | WRR483;1-Piperazinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]carbonyl]butyl]-4-methyl- | | CAS: | 1076088-50-0 | | MF: | C29H41N7O4S | | MW: | 583.75 | | EINECS: | | | Product Categories: | | | Mol File: | 1076088-50-0.mol |  |
| | WRR483 Chemical Properties |
| | WRR483 Usage And Synthesis |
| Description | WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease. | | Uses | WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease. | | References | [1] In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi |
| | WRR483 Preparation Products And Raw materials |
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