Azido-PEG4-Val-Cit-PAB-OH manufacturers
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| | Azido-PEG4-Val-Cit-PAB-OH Basic information |
| Product Name: | Azido-PEG4-Val-Cit-PAB-OH | | Synonyms: | Azido-PEG4-Val-Cit-PAB-OH;N3-PEG4-Val-Cit-PAB;1-azido-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12-tetraoxapentadecan-15-amide | | CAS: | 2055024-64-9 | | MF: | C29H48N8O9 | | MW: | 652.75 | | EINECS: | | | Product Categories: | ADC LINKER | | Mol File: | 2055024-64-9.mol |  |
| | Azido-PEG4-Val-Cit-PAB-OH Chemical Properties |
| form | Solid | | color | White to off-white |
| | Azido-PEG4-Val-Cit-PAB-OH Usage And Synthesis |
| Description | Azido-PEG4-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group enable click chemistry with DBCO, BCN or other Alkyne group. PEG spacer increases aqueous solubility. | | Uses | Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Protease Cleavable Linker; PEGs; Cleavable Linker | | References | [1] Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. DOI:10.3390/ph11020032
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG4-Val-Cit-PAB-OH Preparation Products And Raw materials |
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