Azido-PEG3-Val-Cit-PAB-OH manufacturers
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| | Azido-PEG3-Val-Cit-PAB-OH Basic information |
| Product Name: | Azido-PEG3-Val-Cit-PAB-OH | | Synonyms: | Azido-PEG3-Val-Cit-PAB-OH;N3-PEG3-Val-Cit-PAB;L-Ornithinamide, N-[3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | | CAS: | 2055024-65-0 | | MF: | C27H44N8O8 | | MW: | 608.7 | | EINECS: | | | Product Categories: | ADC LINKER | | Mol File: | 2055024-65-0.mol |  |
| | Azido-PEG3-Val-Cit-PAB-OH Chemical Properties |
| solubility | Soluble in Water, DMSO, DMF |
| | Azido-PEG3-Val-Cit-PAB-OH Usage And Synthesis |
| Description | Azido-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. | | Uses | Azido-PEG3-Val-Cit-PAB-OH is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Protease Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | Azido-PEG3-Val-Cit-PAB-OH Preparation Products And Raw materials |
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