N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide

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N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide manufacturers
N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide Basic information
Product Name:N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide
Synonyms:N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide;SARS-CoV-2 nsp13-IN-1;[1,1'-Biphenyl]-4-carboxamide, N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)phenyl]-;N-(4-(2-Methyl-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)phenyl)-[1,1'-biphenyl]-4-carboxamide;N-(4-(2-Methyl-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)phenyl)-[1,1'-biphenyl]-4-carboxamide
CAS:1005304-44-8
MF:C27H20N4O2
MW:432.47
EINECS:
Product Categories:
Mol File:1005304-44-8.mol
N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide Structure
N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide Chemical Properties
density 1.26±0.1 g/cm3(Predicted)
pka12.68±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide Usage And Synthesis
UsesSARS-CoV-2 nsp13-IN-1 (compound C1) is a potent nsp13 (non-structural protein 13) inhibitor. SARS-CoV-2 nsp13-IN-1 only inhibits nsp13 ssDNA+ ATPase, with an IC50 of 6 μM. SARS-CoV-2 nsp13-IN-1 does not inhibit ssDNA- ATPase. SARS-CoV-2 nsp13-IN-1 can be used for COVID-19 research[1].
References[1] Yazdi AK, et al. Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. ACS Infect Dis. 2022 Jul 13. DOI:10.1021/acsinfecdis.2c00165
N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide Preparation Products And Raw materials
Tag:N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide(1005304-44-8) Related Product Information
N-[4-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide Benzamide, N-[3-(2-methyl-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)phenyl]-4-(trifluoromethyl)- 3-(3-Ethyl-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl)-propionic acid 4H-Dipyrrolo[1,2-a:2′,3′-d]pyrimidin-4-one, 1,6,7,8-tetrahydro-7,7-dimethyl- 3-(4-amino-3-fluorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4-one 3-(piperidin-4-yl)pyrido[2,3-d]pyrimidin-4(3H)-one