QDVBJHFEZRTDHU-QAQDUYKDSA-N manufacturers
- QQN-00358
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- $1970.00
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2026-05-11
- CAS:1498300-35-8
- Purity:
- Supply Ability: 10g
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| | QDVBJHFEZRTDHU-QAQDUYKDSA-N Basic information |
| Product Name: | QDVBJHFEZRTDHU-QAQDUYKDSA-N | | Synonyms: | QDVBJHFEZRTDHU-QAQDUYKDSA-N;Cyclohexanecarboxylic acid, 4-[[1-[[2-cyano-3-(trifluoromethyl)phenyl]methyl]-1,4-dihydro-5-methyl-2,4-dioxo-3(2H)-quinazolinyl]methyl]-, trans-;QQN-00358 | | CAS: | 1498300-35-8 | | MF: | C26H24F3N3O4 | | MW: | 499.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1498300-35-8.mol |  |
| | QDVBJHFEZRTDHU-QAQDUYKDSA-N Chemical Properties |
| Boiling point | 665.1±65.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | pka | 4.82±0.10(Predicted) |
| | QDVBJHFEZRTDHU-QAQDUYKDSA-N Usage And Synthesis |
| Description | QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor. | | Uses | TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1]. | | References | [1] Qin D,et al. Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010. DOI:10.1021/acsmedchemlett.1c00160 |
| | QDVBJHFEZRTDHU-QAQDUYKDSA-N Preparation Products And Raw materials |
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