| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:FARNESYLPYROPHOSPHATE
CAS:13058-04-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-400-164-7117 18317119277 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate
CAS:13058-04-3
Purity:98% Package:1mg;5mg;10mg Remarks:BD129996
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| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
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| Tel: |
15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:Farnesyl pyrophosphate ammonium salt methanol:ammonia solution
CAS:13058-04-3
Purity:95%， 1 mg/mL in methanol:ammonia solution Package:200μg；1mg；5mg
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| | FARNESYLPYROPHOSPHATE Basic information |
| Product Name: | FARNESYLPYROPHOSPHATE | | Synonyms: | FARNESYLPYROPHOSPHATE TRIAMMONIUM SALT SOLUTION;FPP, 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt;(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-triene-1-ol diphosphoric acid;(E,E)-Farnesyl pyrophosphate;3,7,11-TRIMETHYL-2,6,10-DODECATRIEN-1-OL PYROPHOSPHATE;3,7,11-TRIMETHYL-2,6,10-DODECATRIEN-1-OL PYROPHOSPHATE 3NH3;3,7,11-TRIMETHYL-2,6,10-DODECATRIEN-1-OL PYROPHOSPHATE AMMONIUM SALT;FARNESYL PYROPHOSPHATE AMMONIUM SALT | | CAS: | 13058-04-3 | | MF: | C15H28O7P2 | | MW: | 382.33 | | EINECS: | | | Product Categories: | | | Mol File: | 13058-04-3.mol |  |
| | FARNESYLPYROPHOSPHATE Chemical Properties |
| Melting point | >107°C (dec.) | | Boiling point | 533.8±60.0 °C(Predicted) | | density | 1.233±0.06 g/cm3(Predicted) | | Fp | 11 °C | | storage temp. | -20°C | | solubility | Methanol (Slightly, Sonicated), Water (Slightly) | | pka | 1.07±0.50(Predicted) | | form | methanol:ammonia solution | | color | White to Brown | | Stability: | Hygroscopic, Light Sensitive, Temperature Sensitive | | InChI | 1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+ | | InChIKey | VWFJDQUYCIWHTN-YFVJMOTDSA-N | | SMILES | C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O |
| Hazard Codes | F,T | | Risk Statements | 11-23/24/25-39/23/24/25 | | Safety Statements | 7-16-36/37-45 | | RIDADR | UN 1230 3/PG 2 | | WGK Germany | 1 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 1 |
| | FARNESYLPYROPHOSPHATE Usage And Synthesis |
| Uses | Farnesyl pyrophosphate ammonium salt has been used:
- as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays
- in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)
- as a substrate in prenyltransferases assay in diatom Haslea ostrearia
| | Definition | ChEBI: 2-trans,6-trans-farnesyl diphosphate is the trans,trans-stereoisomer of farnesyl diphosphate. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a 2-trans,6-trans-farnesyl diphosphate(3-). | | General Description | Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS). | | Biochem/physiol Actions | Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease. | | Purification Methods | Purify the pyrophosphate by chromatography on Whatman No3 MM paper in a system of isopropanol-isobutanol/ammonia/water (40:20:1:30) (v/v). Store it as the Li or NH4 salt at 0o. See geranylgeranyl pyrophosphate below. |
| | FARNESYLPYROPHOSPHATE Preparation Products And Raw materials |
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