| Company Name: |
Accela ChemBio Inc.
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+1(858) 699-3322 |
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marketing@accelachem.com |
| Products Intro: |
Product Name:2-AMino-2-[3-(trifluoroMethyl)phenyl]acetic Acid Hydrochloride
CAS:1134915-25-5
Purity:97+% Package:5g
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| | 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE Basic information |
| Product Name: | 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE | | Synonyms: | 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE;AMINO[3-(TRIFLUOROMETHYL)PHENYL]ACETIC ACID HYDROCHLORIDE;rel-(2R)-2-amino-2-[3-(trifluoromethyl)phenyl]acetic acid hydrochloride;2-amino-2-[3-(trifluoromethyl)phenyl]acetic acid,hydrochlor;2-(3-Trifluoromethylphenyl)glycine (hydrochloride) | | CAS: | 1134915-25-5 | | MF: | C9H9ClF3NO2 | | MW: | 255.62 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature |
| | 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE Usage And Synthesis |
| Uses | 2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research[1]. | | Synthesis | Example 95A: Synthesis of 2-amino-2-(3-trifluoromethylphenyl)acetic acid hydrochloride
1.00 g (3.13 mmol) of N-tert-butoxycarbonyl-2-(3-trifluoromethylphenyl)-DL-glycine was mixed with 15.7 mL of a dioxane solution of 4N HCl and stirred overnight at room temperature. Upon completion of the reaction, the volatile components were removed using a rotary evaporator. The residue was dried under high vacuum (HV) to give 795 mg (99% of theoretical yield) of 2-amino-2-(3-trifluoromethylphenyl)acetic acid hydrochloride.LC/MS [Method 2]: rt = 0.79 min; m/z = 220 (M + H)+. | | References | [1] Ulf Brüggemeier, et al. Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof. WO2010105770A1 |
| | 2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE Preparation Products And Raw materials |
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