|
|
| | AKTIDE-2T Basic information |
| Product Name: | AKTIDE-2T | | Synonyms: | ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA;AKTIDE-2T;AKT/PKB/RAC-PROTEIN KINASE SUBSTRATE [ARKRERTYSFGHHA];ARKRERTYSFGHHA;H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH;AKT/PKB/Rac - Protein Kinase Substrate;Substrate for AKT/PKB/Rac-protein Kinase;L-Alanine, L-alanyl-L-arginyl-L-lysyl-L-arginyl-L-α-glutamyl-L-arginyl-L-threonyl-L-tyrosyl-L-seryl-L-phenylalanylglycyl-L-histidyl-L-histidyl- | | CAS: | 324029-01-8 | | MF: | C74H114N28O20 | | MW: | 1715.87 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 324029-01-8.mol |  |
| | AKTIDE-2T Chemical Properties |
| storage temp. | Desiccate at -20°C | | Sequence | Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala |
| | AKTIDE-2T Usage And Synthesis |
| Uses | AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1]. | | References | [1] T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15. DOI:10.1074/jbc.M005497200
[2] Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35. DOI:10.1074/jbc.M303417200 |
| | AKTIDE-2T Preparation Products And Raw materials |
|