ASP 7663;ASP-7663;ASP7663
| 中文名称 | ASP 7663;ASP-7663;ASP7663 |
|---|---|
| 中文同义词 | 化合物ASP7663;ASP 7663,TRPA1激活剂;(E)-2-(7-氟-1-异丁基-2-氧代吲哚啉-3-亚基)乙酸;化合物ASP7663,10 MM DMSO 溶液;ASP7663 试剂;ASP7663 试剂;ASP7663/1190217-35-6/98%;ASP 7663,TRPA1激活剂【CAS:1190217-35-6】【规格:25mg】【纯度:≥98%(HPLC)】 |
| 英文名称 | ASP7663 |
| 英文同义词 | ASP7663;(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid;ASP 7663;ASP-7663;ASP7663;Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-;ASP7663 >=98% (HPLC);pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663;(E)-2-(7-Fluoro-1-isobutyl-2-oxoindolin-3-ylidene)acetic acid;ASP7663, 10 mM in DMSO |
| CAS号 | 1190217-35-6 |
| 分子式 | C14H14FNO3 |
| 分子量 | 263.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1190217-35-6.mol |
| 结构式 |  |
ASP 7663;ASP-7663;ASP7663 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：25mg/mL，乙醇：25mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至橙色 |
| InChI | 1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+ |
| InChIKey | RCVZUIGCNAAMIC-UXBLZVDNSA-N |
| SMILES | CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O |
ASP7663 concentration dependently increases intracellular Ca
2+
concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC
50
values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice.
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide.
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat.
| Animal Model: | CRD model (colorectal distension in rat). |
| Dosage: | 1 and 3 mg/kg. |
| Administration: | Orally. |
| Result: | Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0447 | ASP 7663;ASP-7663;ASP7663 ASP7663 | 1190217-35-6 | 5mg | 2560.76元 |
| 2026/07/06 | S0447 | ASP 7663;ASP-7663;ASP7663 ASP7663 | 1190217-35-6 | 25mg | 7396.78元 |