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| | N,N'-Dinitrosopiperazine Basic information |
| | N,N'-Dinitrosopiperazine Chemical Properties |
| Melting point | 208-210°C | | Boiling point | 262.72°C (rough estimate) | | density | 1.4165 (rough estimate) | | refractive index | 1.8500 (estimate) | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | -4.82±0.70(Predicted) | | color | White to Pale Yellow | | Water Solubility | 5.765g/L(24 ºC) | | Henry's Law Constant | 1.9×102 mol/(m3Pa) at 25℃, Mirvish et al. (1976) | | Stability: | Hygroscopic | | InChI | InChI=1S/C4H8N4O2/c9-5-7-1-2-8(6-10)4-3-7/h1-4H2 | | InChIKey | WNSYEWGYAFFSSQ-UHFFFAOYSA-N | | SMILES | N1(N=O)CCN(N=O)CC1 | | CAS DataBase Reference | 140-79-4 | | EPA Substance Registry System | Piperazine, 1,4-dinitroso- (140-79-4) |
| | N,N'-Dinitrosopiperazine Usage And Synthesis |
| Chemical Properties | Pale Yellow Solid | | Uses | N,N'-Dinitrosopiperazine (DNP) induces nasopharyngeal carcinoma (NPC) and shows organ specificity to the nasopharyneal epithelium. | | Safety Profile | Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by ingestion, subcutaneous, and
intraperitoned routes. Experimental
reproductive effects. Human mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx. See also NNITROSO COMPOUNDS. | | in vivo | N,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice[1]. | Animal Model: | BABL/c nude mice injected with labeled 6-10B cell suspensions (1×104cells) with or without DNP(40 mg/kg)[1] | | Dosage: | 40 mg/kg | | Administration: | Injected into the tail veins; 30 days | | Result: | Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo. |
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| | N,N'-Dinitrosopiperazine Preparation Products And Raw materials |
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