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BOC Sciences
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| Products Intro: |
Product Name:MRT-81
CAS:1263132-08-6
Remarks:Reach out to us for more information about custom solutions.
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3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide manufacturers
- MRT-81
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- $59.00
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2026-07-14
- CAS:1263132-08-6
- Purity: 99.72%
- Supply Ability: 10g
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| | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Basic information |
| Product Name: | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide | | Synonyms: | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide;MRT-81;Smo,Smoothened,human,C3H10T1/2 cells,inhibit,Shh-light2 cells,rodent,BODIPY-cyclopamine,MRT81,MRT-81,rat granule cell precursors,Inhibitor,MRT 81;[1,1'-Biphenyl]-4-carboxamide, N-[2-methyl-5-[[thioxo[(3,4,5-trimethoxybenzoyl)amino]methyl]amino]phenyl]-;N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)thioureido)phenyl)-[1,1'-biphenyl]-4-carboxamide;MRT-81, 10 mM in DMSO;MRT-81 ，E0480 | | CAS: | 1263132-08-6 | | MF: | C31H29N3O5S | | MW: | 555.64 | | EINECS: | | | Product Categories: | | | Mol File: | 1263132-08-6.mol | ![3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Structure](CAS/20180719/GIF/1263132-08-6.gif) |
| | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Chemical Properties |
| density | 1.289±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 8.09±0.70(Predicted) | | form | Solid | | color | White to light yellow |
| | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Usage And Synthesis |
| Uses | MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1]. | | Biological Activity | MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1].
MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM[1].MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM[1].MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM; 2 h; 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells[1]. | | References | [1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012 Feb 23;55(4):1559-71. |
| | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Preparation Products And Raw materials |
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