| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
Myxothiazol manufacturers
- Myxothiazol
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- $2.00
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2026-08-25
- CAS:76706-55-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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| | Myxothiazol Basic information |
| Product Name: | Myxothiazol | | Synonyms: | MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;5-dimethoxy-4-methyl-;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;myxothiazol from myxobacterium*myxococcus fulvus;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;myxothiazolfrommyxobacterium;2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)- | | CAS: | 76706-55-3 | | MF: | C25H33N3O3S2 | | MW: | 487.68 | | EINECS: | | | Product Categories: | Inhibits an EnzymeNitric Oxide and Cell Stress;Mitochondrial InhibitorsAntibiotics;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;AntifungalAntibiotics;Cell Stress;Chemical Structure Class;Mechanism of Action;Peptides;Spectrum of Activity | | Mol File: | 76706-55-3.mol |  |
| | Myxothiazol Chemical Properties |
| Boiling point | 679.6±65.0 °C(Predicted) | | density | 1.158±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow | | form | Solid | | pka | 14.07±0.50(Predicted) | | color | White to off-white | | biological source | Myxococcus fulvus Mx f85 | | InChIKey | XKTFQMCPGMTBMD-ZDBABOMLSA-N | | SMILES | CO[C@@H](\C=C\c1csc(n1)-c2csc(n2)[C@@H](C)\C=C\C=C\C(C)C)[C@@H](C)\C(OC)=C\C(N)=O |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 28-36/37-45 | | RIDADR | UN 3462 6.1/PG 1 | | WGK Germany | 3 | | RTECS | QH7580000 | | F | 10 | | HazardClass | 6.1(b) | | PackingGroup | III | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral |
| | Myxothiazol Usage And Synthesis |
| Uses | Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation. | | Definition | ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S | | Biochem/physiol Actions | Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone. | | in vivo | Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3]. | Animal Model: | C57Bl/J6 mice[3] | | Dosage: | 0.56 mg/kg | | Administration: | I.p.; 24 hours intervals for at most 4 times | | Result: | A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
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| | Myxothiazol Preparation Products And Raw materials |
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