MMP INHIBITOR I

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MMP INHIBITOR I manufacturers

  • FN-439
  • FN-439 pictures
  • $2120.00
  • 2026-07-27
  • CAS:124168-73-6
  • Purity:
  • Supply Ability: 10g
MMP INHIBITOR I Basic information
Product Name:MMP INHIBITOR I
Synonyms:P-aminobenzoyl-gly-pro-D-leu-D-ala*hydroxamic aci;4-ABZ-GLY-PRO-D-LEU-D-ALA-NHOH;METALLOPROTEASE INHIBITOR 1;MATRIX METALLOPROTEINASE INHIBITOR I;4-aminobenzoyl-gly-pro-d-leu-d-ala hydroxamic acid;D-AlaninaMide, N-(4-aMinobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-;4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt;H-4-ABZ-GLY-PRO-D-LEU-D-ALA-NHOH
CAS:124168-73-6
MF:C23H34N6O6
MW:490.55
EINECS:
Product Categories:Inhibitor of human matrix metalloproteinases.
Mol File:124168-73-6.mol
MMP INHIBITOR I Structure
MMP INHIBITOR I Chemical Properties
density 1.288±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility H2O: 1 mg/mL
pka9.34±0.40(Predicted)
form solid
color white
Water Solubility water: 1mg/mL
InChIKeyWWHUHFFMOPIVKB-OLMNPRSZSA-N
SMILESCC(C)C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)c2ccc(N)cc2)C(=O)N[C@H](C)C(=O)NO
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
MMP INHIBITOR I Usage And Synthesis
UsesFN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].
Biological ActivityCollagenase Inhibitor
in vivo

FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2].

References[1] U Benbow, et al. Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid. Clin Exp Metastasis. 1999 May;17(3):231-8. DOI:10.1023/a:1006639214618
[2] H Anan, et al. Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J Endod. 1996 Dec;22(12):668-73. DOI:10.1016/S0099-2399(96)80061-6
MMP INHIBITOR I Preparation Products And Raw materials
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