BI 6901 manufacturers
- BI-6901
-
- $126.00
-
2026-07-27
- CAS:2040401-92-9
- Purity: 99.98%
- Supply Ability: 10g
|
| | BI 6901 Basic information |
| Product Name: | BI 6901 | | Synonyms: | BI 6901;BI6901,BI 6901;1H-Indole-4-sulfonamide, N-[(1R)-3-(2-cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]- | | CAS: | 2040401-92-9 | | MF: | C23H27N5O3S | | MW: | 453.56 | | EINECS: | | | Product Categories: | | | Mol File: | 2040401-92-9.mol |  |
| | BI 6901 Chemical Properties |
| Boiling point | 736.8±70.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | | form | Solid | | pka | 9.66±0.50(Predicted) | | color | White to off-white |
| | BI 6901 Usage And Synthesis |
| Uses | BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1]. | | Biological Activity | BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].
BI-6901 (intraperitoneal injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1]. | | in vivo | BI-6901 (intraperitonealinjection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1]. | Animal Model: | Balb-C mice with a DNFB model of contact hypersensitivity. | | Dosage: | 100 mg/kg | | Administration: | Intraperitonealinjection | | Result: | Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice. |
| | storage | Store at -20°C | | References | [1]. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. |
| | BI 6901 Preparation Products And Raw materials |
|