VU 0409106

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VU 0409106 Suppliers list
Company Name: Shanghaizehan biopharma technology co., Ltd.  
Tel: 021-61350663 13052117465
Email: sales@zehanbiopharma.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: BOC Sciences  
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Email: info@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn

VU 0409106 manufacturers

  • VU0409106
  • VU0409106 pictures
  • $575.00
  • 2026-07-14
  • CAS:1276617-62-9
  • Purity: 99.89%
  • Supply Ability: 10g
VU 0409106 Basic information
Product Name:VU 0409106
Synonyms:VU 0409106;3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide;Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)-;3-Fluoro-N-(4-methylthiazol-2-yl)-5-(pyrimidin-5-yloxy)benzamide
CAS:1276617-62-9
MF:C15H11FN4O2S
MW:330.34
EINECS:
Product Categories:
Mol File:1276617-62-9.mol
VU 0409106 Structure
VU 0409106 Chemical Properties
density 1.445±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka6.61±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
VU 0409106 Usage And Synthesis
UsesVU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.
in vivo

VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].

Animal Model:CD-1 mice[1]
Dosage:10 mg/kg (10% Tween 80 formulation)
Administration:Intraperitoneal injection.
Result:1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
IP (10 mg/kg)
Plasma Tmax (h)0.25
Plasma Cmax (ng/mL)1450
Brain Tmax (h)0.25
Brain Cmax (ng/mL)1350
AUCplasma (ng/mLh)702
AUCbrain (ng/mLh)696
B/P ratio0.99
IC 50mGlu5: 24 nM (IC50)
VU 0409106 Preparation Products And Raw materials
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