K-604 dihydrochloride

Request For Quotation
K-604 dihydrochloride Suppliers list
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Email: isunpharm@qq.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Email: liming@bio-fount.com

K-604 dihydrochloride manufacturers
K-604 dihydrochloride Basic information
Product Name:K-604 dihydrochloride
Synonyms:K-604 dihydrochloride;K-604 (K604);K-604 >=98% (HPLC);K-604 2HCl;2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide dihydrochloride;K604,K604 dihydrochloride,acyl-CoA:cholesterol acyltransferase,K-604,inhibit,K 604,Inhibitor,Diacylglycerol acyltransferase,Diglyceride acyltransferase,mono- acylglycerol acyltransferase,Acyltransferase,K 604 dihydrochloride;K-604 dihydrochloride, 10 mM in DMSO
CAS:217094-32-1
MF:C23H31ClN6OS3
MW:539.17
EINECS:
Product Categories:
Mol File:217094-32-1.mol
K-604 dihydrochloride Structure
K-604 dihydrochloride Chemical Properties
storage temp. 2-8°C
solubility DMSO: 62.5 mg/mL (108.57 mM)
form Solid
color white to beige
InChIKeyDEKWEGUBUYKTAV-UHFFFAOYSA-N
SMILESO=C(NC1=C(SC)C=C(C)N=C1SC)CN2CCN(CCSC3=NC4=CC=CC=C4N3)CC2.[H]Cl.[H]Cl
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
K-604 dihydrochloride Usage And Synthesis
UsesK-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.
Biological ActivityK-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with IC50 of 0.45±0.06 μM.
in vivoUsing F1B hamsters, an animal model susceptible to diet-induced hyperlipidemia and atherosclerosis, the effects of K-604 dihydrochloride on aortic lesion areas and plasma cholesterol levels are assessed.
target

ACAT-1

< span> 0.45 μM (IC 50 )

ACAT-2

102.85 μM (IC 50 )

IC 50ACAT-1: 0.45 μM (IC50); ACAT-2: 102.85 μM (IC50)
References[1] Ikenoya M, et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7. DOI:10.1016/j.atherosclerosis.2006.05.048
[2] Shibuya Y, et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging. 2015 Jul;36(7):2248-2259. DOI:10.1016/j.neurobiolaging.2015.04.002
K-604 dihydrochloride Preparation Products And Raw materials
Tag:K-604 dihydrochloride(217094-32-1) Related Product Information
2-[4-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]piperazin-1-yl]-N-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]acetamide 4-Hydroxy-L-phenylglycine 2-Furoic acid [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate DGAT-3 Avasimibe