CDK5 inhibitor 20-223 (CP 668863)

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CDK5 inhibitor 20-223 (CP 668863) manufacturers
CDK5 inhibitor 20-223 (CP 668863) Basic information
Product Name:CDK5 inhibitor 20-223 (CP 668863)
Synonyms:CDK5 inhibitor 20-223 (CP 668863);CDK5 inhibitor 20-223;2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-;CDK5 inhibitor 20223,CDK5 inhibitor 20 223,CDK-5 inhibitor 20-223;CDK5 inhibitor
CAS:865317-30-2
MF:C19H19N3O
MW:305.37
EINECS:
Product Categories:
Mol File:865317-30-2.mol
CDK5 inhibitor 20-223 (CP 668863) Structure
CDK5 inhibitor 20-223 (CP 668863) Chemical Properties
storage temp. Store at -20°C
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
CDK5 inhibitor 20-223 (CP 668863) Usage And Synthesis
UsesCDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent[1].
in vivo

CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1].

Animal Model:Athymic nude mice[1]
Dosage:8 mg/kg
Administration:Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections.
Result:Reduced tumor growth and tumor weight in vivo.
IC 50CDK2: 6.0 nM (IC50); CDK5: 8.8 nM (IC50)
References[1] Caroline M Robb, et al. Characterization of CDK(5) Inhibitor, 20-223 (Aka CP668863) for Colorectal Cancer Therapy. Oncotarget. 2017 Dec 28;9(4):5216-5232. DOI:10.18632/oncotarget.23749
CDK5 inhibitor 20-223 (CP 668863) Preparation Products And Raw materials
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