CDK5 INHIBITOR 20-223
| 中文名称 | CDK5 INHIBITOR 20-223 |
|---|---|
| 中文同义词 | |
| 英文名称 | CDK5 inhibitor 20-223 (CP 668863) |
| 英文同义词 | CDK5 inhibitor 20-223 (CP 668863);CDK5 inhibitor 20-223;2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-;CDK5 inhibitor 20223,CDK5 inhibitor 20 223,CDK-5 inhibitor 20-223;CDK5 inhibitor |
| CAS号 | 865317-30-2 |
| 分子式 | C19H19N3O |
| 分子量 | 305.37 |
| EINECS号 | |
| 相关类别 | 制剂-抑制剂 |
| Mol文件 | 865317-30-2.mol |
| 结构式 |  |
CDK5 INHIBITOR 20-223 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
CDK5 inhibitor 20-223 是一种有效的 CDK2 和 CDK5 抑制剂，IC50 分别为 6.0 和 8.8 nM。CDK5 inhibitor 20-223 有潜力用于结肠直肠癌 (CRC) 的研究。
|
CDK2 6.0 nM (IC 50 ) |
CDK5 8.8 nM (IC 50 ) |
CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines.
CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines.
Cell Viability Assay
| Cell Line: | CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells |
| Concentration: | 10 μM, 1 μM, 100 nM, 10 nM |
| Incubation Time: | 72 hours |
| Result: | Reduced cell growth. IC50s of 168±20, 480±41, 360±72, 763±92, 117±49, 568±49, 79±31 nM for SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells. |
Western Blot Analysis
| Cell Line: | CRC cell lines GEO, HCT116 and HT29 |
| Concentration: | 20, 10, 5, 2.5, 1.25, 0.625, 0.3125 μM |
| Incubation Time: | 6 hours |
| Result: |
Did not affect the total levels of CDK2/5, and the levels of total FAK or total Retinoblastoma protein (Rb).
Induced a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels. |
CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice.
| Animal Model: | Athymic nude mice |
| Dosage: | 8 mg/kg |
| Administration: | Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections. |
| Result: | Reduced tumor growth and tumor weight in vivo. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-123772 | CDK5 inhibitor 20-223 | 865317-30-2 | 1 mg | 909元 |
| 2026/09/15 | HY-123772 | CDK5 INHIBITOR 20-223 CDK5 inhibitor 20-223 | 865317-30-2 | 5mg | 2000元 |