Azidoethyl-SS-propionic NHS ester manufacturers
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| | Azidoethyl-SS-propionic NHS ester Basic information |
| | Azidoethyl-SS-propionic NHS ester Chemical Properties |
| | Azidoethyl-SS-propionic NHS ester Usage And Synthesis |
| Description | Azidoethyl-SS-propionic NHS ester is a Click Chemistry crosslinker. The azide group enables Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The disulfide bond can be cleaved by Dithiothreitol (DTT) reagent | | Uses | Azidoethyl-SS-propionic NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azidoethyl-SS-propionic NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Disulfide Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | Azidoethyl-SS-propionic NHS ester Preparation Products And Raw materials |
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