3-(4-Methylpiperazin-1-yl)aniline

3-(4-Methylpiperazin-1-yl)aniline Suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
Email:	sales4.gd@hwrkchemical.com

3-(4-Methylpiperazin-1-yl)aniline Basic information

Product Name:	3-(4-Methylpiperazin-1-yl)aniline
Synonyms:	3-(4-Methylpiperazin-1-yl)aniline ,97%;3-(4-methylpiperazin-1-yl)benzenamine;Benzenamine, 3-(4-methyl-1-piperazinyl)-;3-(4-Methypiperazin-1-yl)anilin;1-(3-Aminophenyl)-4-methylpiperazine;3-(4-Methyl-1-piperazinyl)aniline;3-(4-METHYLPIPERAZIN-1-YL)ANILINE;AKOS BB-8951
CAS:	148546-99-0
MF:	C11H17N3
MW:	191.27
EINECS:
Product Categories:	PIPERIDINE;Amines and Anilines
Mol File:	148546-99-0.mol

3-(4-Methylpiperazin-1-yl)aniline Chemical Properties

Melting point	98-99
Boiling point	353.1±37.0 °C(Predicted)
density	1.092±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
form	powder to crystal
pka	7.88±0.42(Predicted)
color	White to Yellow to Orange
InChI	InChI=1S/C11H17N3/c1-13-5-7-14(8-6-13)11-4-2-3-10(12)9-11/h2-4,9H,5-8,12H2,1H3
InChIKey	RJGHJWKQCJAJEP-UHFFFAOYSA-N
SMILES	C1(N)=CC=CC(N2CCN(C)CC2)=C1
CAS DataBase Reference	148546-99-0

Safety Information

MSDS Information

3-(4-Methylpiperazin-1-yl)aniline Usage And Synthesis

Uses	3-(4-methylpiperazin-1-yl)aniline is an amine derivative used in organic and pharmaceutical synthesis.
Chemical Properties	Yellow solid
Synthesis	148546-97-8 148546-99-0 Step - (ii): Synthesis of 3-(4-methylpiperazin-1-yl)aniline: A methanolic solution of 1-methyl-4-(3-nitrophenyl)piperazine (15 g, 78.5 mmol) was mixed with a methanolic solution of 10% Pd/C (3 g) under stirring. The reaction was carried out under inert atmosphere with slow stirring and under hydrogen atmosphere for 4 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated to afford the target product 3-(4-methylpiperazin-1-yl)aniline (11 g, 87%) as a light yellow solid. Mass spectrum (electrospray ionization) m/z: 192 (M + 1).
References	[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5221 - 5224 [2] Patent: WO2007/18941, 2007, A2. Location in patent: Page/Page column 96-97 [3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119 [4] RSC Advances, 2018, vol. 8, # 22, p. 11871 - 11885 [5] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 39; 40

3-(4-Methylpiperazin-1-yl)aniline Preparation Products And Raw materials

Raw materials	Dimethyl sulfoxide-->Stannous chloride dihydrate-->1-Methylpiperazine-->1-Fluoro-3-nitrobenzene-->1-Methyl-4-(3-nitrophenyl)piperazine-->Activated carbon-->Palladium-->Hydrogen-->Methanol
Preparation Products	3-(4-methylpiperazin-1-yl)phenol

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