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| Product Name: | Danofloxacin mesylate | | Synonyms: | 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-quinolin-3-carboxylic acid methanesulfonate (1:1);3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-, methanesulfonate (1:1);Mesylate Dan Nuosha star;DANOFLOXACIN MESILATE;DANOFLOXACIN MESULATE;DANOFLOXACIN MESYLATE;DANOFLOXANCIN MESYLATE;1-cyclopropyl-6-fluoro-7-[(1s,4s)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid monomethanesulfonate | | CAS: | 119478-55-6 | | MF: | C19H20FN3O3.CH4O3S | | MW: | 453.49 | | EINECS: | 638-813-3 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 119478-55-6.mol |  |
| | Danofloxacin mesylate Chemical Properties |
| Melting point | 337-339°C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Sonicated) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | InChIKey | APFDJSVKQNSTKF-LWBBREITNA-N | | SMILES | C12C=C(C(F)=CC=1C(C(C(=O)O)=CN2C1CC1)=O)N1C[C@@]2([H])N(C)C[C@]1([H])C2.S(=O)(=O)(O)C |&1:20,25,r| | | CAS DataBase Reference | 119478-55-6(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | WGK 2 | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Chronic 3
STOT RE 2 |
| | Danofloxacin mesylate Usage And Synthesis |
| Description | Danofloxacin is a fluoroquinolone antibiotic and a type II topoisomerase inhibitor. It has a broad antimicrobial spectrum. It can be used as an anti-infective agent for veterinary use only.
| | Brand Name(s) in US | Advocin
| | Reference | J. A. Schrickx, J. Fink-Gremmels, Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters, British Journal of Pharmacology, 2009, vol. 150, pp. 463-469
| | Description | Danofloxacin is a fluoroquinolone antibiotic. In vitro, danofloxacin has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry with MICs ranging from 8 to 500 nM. It is protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of 0.31, 0.40, and 2.42 mg/kg, respectively. Formulations containing danofloxacin are widely used to prevent infectious disease in livestock. | | Chemical Properties | Crystalline Solid | | Uses | Danofloxacin is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM | | Uses | Fluorinated quinolone antibacterial. | | Definition | ChEBI: Danofloxacin mesylate is a member of quinolines. | | Veterinary Drugs and Treatments | Danofloxacin mesylate injection is indicated for the treatment of
Bovine Respiratory Disease (BRD) associated with Mannheimia
(Pasturella) hemolytica and P. multocida in cattle (not dairy or
veal). Because of the drug’s spectrum of activity, it may also be of
benefit in the treatment of infections caused by Histophilus somni
(Haemophilus somnus) or M. bovis, but the drug is not labeled (at
the time of writing) for treating these pathogens. In other countries,
danofloxacin may be labeled for use in swine and chickens
(non-laying), but in the USA it is illegal to use the drug in an extralabel
manner in food-producing species.
Danofloxacin may be of benefit in treating susceptible infections in
adult horses, camelids and other non-food producing species. | | References | [1] A.C. COOPER. In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance[J]. Research in veterinary science, 1993, 54 3: Pages 329-334. DOI: 10.1016/0034-5288(93)90130-8
[2] PAUL R. MCGUIRK. Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine[J]. Journal of Medicinal Chemistry, 1992, 35 4: 611-620. DOI: 10.1021/jm00082a001
[3] MIN YAO. The regulation effects of danofloxacin on pig immune stress induced by LPS[J]. Research in veterinary science, 2017, 110: Pages 65-71. DOI: 10.1016/j.rvsc.2016.11.005 |
| | Danofloxacin mesylate Preparation Products And Raw materials |
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