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| | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Basic information |
| | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | pka | 11.06±0.46(Predicted) | | Sequence | Z-Val-Arg-Pro-{DL-Arg}-{Fluoromethylketone} |
| | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Usage And Synthesis |
| Uses | Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity[1]. | | in vivo | Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (37.5 M*0.2 mL; every other day for 12 days) inhibits the growth of the tumor in mouse[1]. | Animal Model: | 4-6 weeks, 16-20 g, Female BALB/c nude mice (OCI-LY10 cells)[1] | | Dosage: | 37.5 M*0.2 mL | | Administration: | Every other day for 12 days | | Result: | Inhibited the growth of the xenografts and decreased the expression of P65. |
| | References | [1] Feng J, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. PMID:31934017 |
| | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Preparation Products And Raw materials |
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