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FASCAPLYSIN CHLORIDE manufacturers
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| | FASCAPLYSIN CHLORIDE Basic information |
| Product Name: | FASCAPLYSIN CHLORIDE | | Synonyms: | Fascaplysin (chloride)|CDK4 inhibitor;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;fascaplysine;Fascaplysin chloride hydrate;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI);FASCAPLYSIN CHLORIDE;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;Fascaplysin, ATP-competitve CDK4 inhibitor | | CAS: | 114719-57-2 | | MF: | C18H11ClN2O | | MW: | 306.74574 | | EINECS: | | | Product Categories: | | | Mol File: | 114719-57-2.mol |  |
| | FASCAPLYSIN CHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml) | | form | solid | | color | Dark red-brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | | InChI | 1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H | | InChIKey | PWUOOJVYZQILBG-UHFFFAOYSA-N |
| | FASCAPLYSIN CHLORIDE Usage And Synthesis |
| Description | Fascaplysin (114719-57-2) is a novel marine natural product isolated fromThorectandra sp.1A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50= 0.35 μM) and is less selective for Cdk6/D1 (IC50= 3.4 μM). Displays antiangiogenic acitivity.2Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3 | | Uses | Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis. | | in vivo | Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2] | | IC 50 | CDK4 | | References | [1] RAJEEV SONI. Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product[J]. Biochemical and biophysical research communications, 2000, 275 3: Pages 877-884. DOI:10.1006/bbrc.2000.3349
[2] JING LIN Hai M C Xiao Jun Yan. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.[J]. Cancer Chemotherapy and Pharmacology, 2007, 59 4: 439-445. DOI:10.1007/s00280-006-0282-x
[3] HAMILTON G. Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.[J]. Marine Drugs, 2014: 1377-1389. DOI:10.3390/md12031377 |
| | FASCAPLYSIN CHLORIDE Preparation Products And Raw materials |
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