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| | BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL& Basic information |
| | BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL& Chemical Properties |
| Melting point | 160℃ | | Boiling point | 400.0±25.0 °C(Predicted) | | density | 1.225 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 11.82±0.10(Predicted) | | Appearance | Off-white to light brown Solid | | InChI | 1S/C9H11N3/c10-6-5-9-11-7-3-1-2-4-8(7)12-9/h1-4H,5-6,10H2,(H,11,12) | | InChIKey | GJEPMYMUORZPMP-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL& Usage And Synthesis |
| Uses | Polymer-supported Wittig reagent for clean olefinations of carbonyl compounds. | | reaction suitability | reaction type: C-C Bond Formation
reaction type: solution phase peptide synthesis | | Synthesis | GENERAL PROCEDURE: The general procedure for the synthesis of 2-(1H-benzo[d]imidazol-2-yl)ethylamine from o-phenylenediamine and β-alanine was modified with reference to the method of Phillips. L-amino acids were added to a stirring mixture of 4-nitrophthalimide and aqueous hydrochloric acid (5.5 M). The reaction mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the blue reaction mixture was cooled to room temperature and allowed to stand overnight to allow the target product, 2-(1H-benzo[d]imidazol-2-yl)ethylamine, to crystallize and precipitate as hydrochloride. Subsequently, the reaction mixture was neutralized with 1 M K2CO3 solution to release the free base and extracted with ethyl acetate. The organic phase was evaporated to dryness and finally the product was purified by recrystallization from ethanol. | | References | [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 550 - 558
[2] Bulletin de la Societe Chimique de France, 1991, p. 255 - 259
[3] Collection of Czechoslovak Chemical Communications, 1950, vol. 15, p. 196,200 |
| | BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL& Preparation Products And Raw materials |
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