RIPK1-IN-4 manufacturers
- RIPK1-IN-4
-
- $97.00
-
2026-07-27
- CAS:1481641-08-0
- Purity: 99.82%
- Supply Ability: 10g
- RIPK1-IN-4
-
- $97.00
-
2026-07-27
- CAS:1481641-08-0
- Purity: 99.82%
- Supply Ability: 10g
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| | RIPK1-IN-4 Basic information |
| Product Name: | RIPK1-IN-4 | | Synonyms: | RIPK1-IN-4;Urea, N-[4-(1-amino-5-isoquinolinyl)phenyl]-N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]-;RIPK1IN4,RIPK-1-IN-4,RIPK1 IN 4;RIPK1-IN-4, 10 mM in DMSO | | CAS: | 1481641-08-0 | | MF: | C23H23N5O2 | | MW: | 401.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1481641-08-0.mol |  |
| | RIPK1-IN-4 Chemical Properties |
| Boiling point | 535.8±50.0 °C(Predicted) | | density | 1.305±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (622.73 mM) | | pka | 12.71±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | RIPK1-IN-4 Usage And Synthesis |
| Uses | RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1]. | | IC 50 | RIPK1 | | References | [1] Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. DOI:10.1021/ml400382p |
| | RIPK1-IN-4 Preparation Products And Raw materials |
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