AR-A 2 manufacturers
- AR-A 2
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- $1670.00
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2026-05-11
- CAS:220051-79-6
- Purity:
- Supply Ability: 10g
- AR-A 2
-
- $1670.00
-
2025-08-22
- CAS:220051-79-6
- Purity:
- Supply Ability: 10g
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| Product Name: | AR-A 2 | | Synonyms: | AR-A 2;AR-A 000002;Benzamide, 4-(4-morpholinyl)-N-[(2R)-1,2,3,4-tetrahydro-5-methyl-8-(4-methyl-1-piperazinyl)-2-naphthalenyl]-;ARA 2,AR A 2 | | CAS: | 220051-79-6 | | MF: | C27H36N4O2 | | MW: | 448.6 | | EINECS: | | | Product Categories: | | | Mol File: | 220051-79-6.mol |  |
| | AR-A 2 Chemical Properties |
| Boiling point | 697.1±55.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 15.50±0.20(Predicted) |
| | AR-A 2 Usage And Synthesis |
| Uses | AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety. | | IC 50 | 5-HT1B/D Receptor: 20 nM (Ki); 5-HT2A Receptor: 339 nM (Ki); 5-HT1A Receptor: 3070 nM (Ki) | | References | [1] Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499(1-2):67-75. DOI:10.1016/j.ejphar.2004.07.067 |
| | AR-A 2 Preparation Products And Raw materials |
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