UC-857993 manufacturers
- UC-857993
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- $1980.00
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2026-05-11
- CAS:487001-04-7
- Purity:
- Supply Ability: 10g
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| | UC-857993 Basic information |
| Product Name: | UC-857993 | | Synonyms: | UC-857993;Benzo[ij]dicyclopenta[b,g]quinolizine-2-carboxylic acid, 7-(2-chlorophenyl)-3b,6,6a,7,9,9a,10,12a-octahydro- | | CAS: | 487001-04-7 | | MF: | C25H22ClNO2 | | MW: | 403.9 | | EINECS: | | | Product Categories: | | | Mol File: | 487001-04-7.mol |  |
| | UC-857993 Chemical Properties |
| Boiling point | 549.1±50.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | pka | 4.90±0.40(Predicted) |
| | UC-857993 Usage And Synthesis |
| Uses | UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs)[1]. | | References | [1] Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. DOI:10.1074/jbc.M114.634493 |
| | UC-857993 Preparation Products And Raw materials |
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